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1 4 naphthoquinone derivatives

1,4-Naphthoquinone derivatives potently suppress Candida albicans growth, inhibit formation of hyphae and show no toxicity toward zebrafish embryos J Med Microbiol. 2018 Apr;67(4):598-609. doi: 10.1099/jmm..000700. Epub 2018 Feb 20. Authors Monika Janeczko 1. 1,4-Naphthoquinone and its derivatives have shown some efficacy as therapeutic compounds for cancer and inflammation, though their clinical application is limited by their side-effects. To reduce the toxicity of these compounds and optimize their effects, we synthesized two 1,4-naphthoquinone derivatives-2-butylsulfinyl- 1,4-naphthoquinone (BSNQ) and 2-octylsulfinyl-1,4-naphthoquinone (OSNQ. A novel series of substituted 1,4-naphthoquinone derivatives was synthesized and evaluated for antibacterial and antifungal activity. The structures of the novel products were characterized by spectroscopic methods. Among the tested compounds, 3a and 9 are the most effective compounds against M. luteum as potent antibacterial and C. tenuis and A. niger as potent antifungal. These two compounds. The 1,4-naphthoquinone scaffold is known to confer numerous natural products such as shikonin, lapachol, juglone, and menadione, with diverse biological activities [1-5] including anti-bacterial, antifungal, anticancer, and anti-inflammatory activities.Among the naphthoquione class, 6-substituted 1,4-naphthoquinone derivatives have attracted a great deal of interest from scientific community. 1,4-naphthoquinone is the parent structure of the family of 1,4-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 4 of the naphthalene ring. Derivatives have pharmacological properties. It derives from a hydride of a naphthalene

1,4-Naphthoquinone derivatives potently suppress Candida

  1. o-1,4-naphthoquinone com-pounds are considered to be a potential novel class of aromatase inhibitors because of the presence of heme coordinating atoms, i.e., a
  2. o-1,4-naphthoquinone derivatives grafted with S-cyclohexane and aryl/aliphatic amide moieties as key counterparts was performed
  3. 1,4-naphthoquinone derivatives have superior anticancer effects, but their use has been severely limited in clinical practice due to adverse side effects. To reduce the side effects and extend the anticancer effects of 1,4-naphthoqui-none derivatives, 2-(butane-1-sulfinyl)-1,4-naphthoquinone (BQ) and 2‑(octane‑1‑sulfinyl)‑1,4‑naphthoquinone (OQ) were synthesized, and their anticancer.
  4. 1,4-naphthoquinone derivatives, a series of compounds bearing a 2-O-alkyl-, 3-C-alkyl- or 2/3-N-morpholinoalkyl group were synthesized and evaluated for their anticancer activity against five human cancer cell lines in vitro. The cytotoxicity of these derivatives was assayed against HT-29, SW480, HepG2, MCF-7 and HL-60 cells by the MTT assay. Among them, 2-hydroxy-3-farnesyl-1,4-naphthoquinone.
  5. e(0.12 mol.
  6. The molecular docking of 1,4-naphthoquinone derivatives as inhibitors of Polo-like kinase 1 using Molegro Virtual Docker Susi Kusumaningrum 1,2*, Emil Budianto 1, Soleh Kosela 1, Wahono Sumaryono 2, Fifit Juniarti 2 1 Chemistry Department, Faculty of Mathematics and Natural Science, University of Indonesia, Depok Indonesia
  7. Derivatives of 1,4‑naphthoquinone have excellent anti‑cancer effects, but their use has been greatly limited due to their serious side effects. To develop compounds with decreased side effects and improved anti‑cancer activity, two novel types of 1,4‑naphthoquinone derivatives, 2,3‑dihydro‑2,3‑epoxy‑2‑propylsulfonyl‑5,8‑dimethoxy‑1,4‑naphthoquinone (EPDMNQ) and 2,3.

Bifunctionalisation of 1,4-naphthoquinone by the Oxidative Addition of an Alkylamine and Iodine. Journal of Chemical Research 2013, 37 (1) , Synthesis of 2,3-Diaziridinyl-1,4-naphthoquinone Sulfonate Derivatives as Potential Antineoplastic Agents.. ChemInform 1989, 20 (49) https:. 1,4‑Naphthoquinone derivatives have superior anticancer effects, but their use has been severely limited in clinical practice due to adverse side effects. To reduce the side effects and extend the anticancer effects of 1,4‑naphthoquinone derivatives, 2‑(butane‑1‑sulfinyl)‑1,4‑naphthoquinone (BQ) and 2‑(octane‑1‑sulfinyl)‑1,4‑naphthoquinone (OQ) were synthesized, and. A well-documented procedure to prepare 2-amino-1,4-naphthoquinone derivatives is based on the reaction of amines with 1,4-naphthoquinone [9]. This atom-economical method to construct aminoquinones occurs through an addition-oxidation reaction sequence [10]. In a previous work we described that 2-(4-hydroxyphenyl)amino-1,4-naphthoquinone (3), prepared by acid-induced amination of 1,4. Virtual Screening of 2-hydroxy-1,4-naphthoquinone Derivatives as Antimitotic Agent using Molegro Virtual Docker on Polo Like Kinase 1. Susi Kusumaningrum1,2*, Soleh Kosela1, Wahono Sumaryono2, Emil Budianto1, Alfan Danny Arbianto2. 1 Chemistry Department, Faculty of Mathematics and Natural Science, Universiy of Indonesia. 2Center of Pharmaceutical and Medical Technology, Agency for Assessment.

Novel 1,4-naphthoquinone derivatives induce apoptosis via

Procedure for the preparation of methoxylated derivatives

Synthesis of novel 1,4-naphthoquinone derivatives

It was established that 1,4-naphthoquinone amide derivatives and 2-chloro-3-hydroxy-1,4-naphthoquinone decreased the content of lipid peroxidation products in embryo cells in a dose-dependent manner. The investigated compounds cause an increase in superoxide dismutase and catalase activities compared with the control value. The results of the two-factor ANOVA test indicate that 2-chloro-3. The title compound 3 reacts with various electrophiles such as hydrogen halides, benzoyl chloride, iodomethane, and bromine to afford 3-halo derivatives of 2-hydroxy-1,4-naphthoquinone. 3 reacts also with dimethyl sulfide to give a trans-ylidation product; photochemically, furan derivatives are formed with 2-methyl-2-butene, styrene, and phenylacetylene

Certain 1,4-naphthoquinone derivatives of the general formula in particular the compounds plumbagin and lapacholes, have been shown to increase phagocytosis in high dilutions and are used according to the invention in concentrations in the range from 10-3> to 10-6> mg/ml for immunostimulation CB533 is a synthetic 1,4-naphthoquinone (1,4-NQ) derivative related to e.g. plumbagin, a highly-studied compound with known anticancer activity (Fig. 1) [6, 7]. To compare the activity of CB533 against these two molecules, A375 cells were plated and growth-suppressive activity of CB533, 1,4-NQ and plumbagin was tested in a dose-response assay with compound concentrations between 10 nM and 10. In this study, we synthesized a series of new 1,4-naphthoquinone (1,4-NQ) derivatives and investigated their antagonistic effects against mouse P2X7R. We explored the ability of the tested. 1,4-Naphthoquinone derivatives were found to significantly affect some fungal strains and suppress various bacteria growth, hyphal formation and cell aggregation. 55) A series of novel, substituted 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones (30 -36) have been shown to exhibit promising antimicrobial activity against Plasmodium falciparum, Mycobacterium tuberculosis and P. Triazole-linked 1,4-naphthoquinone derivatives : synthesis and antiplasmodial activity . By Chané Erasmus. Abstract. MSc (Pharmaceutical Chemistry), North-West University, Potchefstroom Campus, 2019Malaria is a protozoan disease transmitted to humans through female Anopheles mosquitoes. The malaria parasite thrives in tropical areas, thus people there are at higher risk, especially in third.

sulfanylamino-1,4-naphthoquinone derivatives have been obtained from the nucleophilic substitution reactions of 1,4-napthoquinones possessing an aryl amine substituent which has two electron donating groups, in the 2,4- and 3,5-positions of phenyl ring, with alkyl mercaptans. The products have been purified by column chromatography and characterized by FTIR, 1D/2D NMR and mass spectroscopy. In a sense, both the reactions of 1,2-naphthoquinone and 1,4-naphthoquinone with primary amines are equivalent, as both reactions lead to formation of 2-amino 1,4-naphthoquinone derivatives as illustrated in Scheme 2. We have already reported the reaction of p -methoxy aniline with 1,4-naphthoquinone leading to the 2- ( p -methoxy-anilino) 1,4.

6-Substituted 1,4-naphthoquinone oxime derivatives (I

Compound 1 (2,3-dichloro-1,4-naphthoquinone) was used as a prototype or a parent compound for comparison with its derivatives as 2-amino-3-chloro-1,4-naphthoquinones (2-11). It was found that compound 4 was the only one that exhibited experimental activity comparable to that of compound 1 (highly active), whereas the rest of the compounds displayed lower potent activity (moderately to weakly. Synthesis and Evaluation of 2-Hydroxy-1,4-Naphthoquinone Derivatives as Potent Antimalarial Agents Wanthani Paengsri,a,b Napapha Promsawan,*,a and Apiwat Barameea a Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand: and bCenter of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand. Seventeen derivatives of [1,4]naphthoquinone were pre-pared by know methods and their structures were con-firmed by infrared spectroscopy, NMR, and mass spec-trometry. Some of the title compounds are analogues of 2-amino-derivatives of lapachol and nor-lapachol re-portedelsewhere(Silvaetal. 2005,Barbosaetal. 2005). All the nitrogen compounds were readily obtained by nucleophilic displacement.

The 1,4-naphthoquinones (1,4-NQs) are a diverse group of natural products found in every kingdom of life. Plants, including many horticultural species, collectively synthesize hundreds of. The chromatographic characteristics are investigated for six derivatives of 1,4-naphthoquinone under conditions of normal-phase thin-layer chromatography for benzene-based binary eluent and such enhancing polar solvents as chloroform, acetoneand propan-2-ol. The slope in the Soczewinski equation for the investigated compounds satisfactorily correlates with the area occupied by the adsorbed. 1,4-naphthoquinone with 4-aminothiophenol in an NMR tube is studied to explain that 2-(4-anilinothiolato) 1,4-naphthoquinone derivative to be the sole product in the reaction. Background Amino quinones are used as medicines, [1-3] herbicides [4] and they also show interesting redox switching properties. [5] Amino quinones are formed in the reactions of different amines with quinones. [6-13. Previous studies on the anticancer activities of this 1,4-naphthoquinone derivative are mostly focused on its cytotoxic properties via the induction of apoptosis and necrosis (Ding et al. It is worth mentioning that ROS generation and modulation of intracellular signalling pathways have also been associated with the anti-metastatic effects of other 1,4-naphthoquinone derivatives 1,4Naphthoquinone or paranaphthoquinone is an organic compound derived from naphthalene. Several isomeric naphthoquinones are known, notably 1,2naphthoquinone. 1,4Naphthoquinone forms volatile yellow triclinic crystals and has a sharp odor similar to benzoquinone. It is almost insoluble in cold . Alchetron. Harman: Home: Sign in. 1,4 Naphthoquinone. Updated on Jan 09, 2018. Edit Like Comment.

1,4-Naphthoquinone C10H6O2 - PubChe

N-derivatives of 1,4- naphthoquinone are widely studied and described, but still remains a significant area of unknown amino acid derivatives of 1,4-naphthoquinone. It is significant interest from a synthetic point of view, because of free, reactive capable carboxyl group of amino acid derivatives of 1,4-naphthoquinone, which can be used as base, for the synthesis of new biologically active. Many naphthoquinone derivatives are haemolytic agents, while others cause necrosis of tubular epithelial cells. In the present study, the short-term toxicity of 16 derivatives of 1,2- and 1,4-naphthoquinone has been examined in rats in order to give information on structure-activity relationships. All the naphthoquinones except one caused. The incorporation of sulphur atom in 1,4-naphthoquinone derivatives has led to antifungal, antibacterial, antiviral, and anticancer activities [12e16].It has been reported that menadione (an analogue of 1,4naphthoquinone) could induce reactive oxygen species (ROS), which mediate DNA damage in many human cultured cells, suggesting that this activity might be important for its therapeutic. In this way, our study aimed to evaluate the cytotoxicity and selectiveness of four 2,3-triazole-1,4-naphthoquinone derivatives (N1-N4) towards the CRC cell line HT-29 and normal human cells. MTT assay showed that N1, N2, N3 and N4 elicited distinct cytotoxic potency, exhibiting EC50 values of 40.6 ± 1.0, 100.1 ± 1.0, 241.9 ± 1.2 and 101.9 ± 1.1, respectively. Later, flow cytometry in HT.

Antibacterial Activity of 2-Amino-1,4-naphthoquinone Derivatives against Gram-Positive and Gram-Negative Bacterial Strains and Their Interaction with Human Serum Albumin. Carla C. da Silva # These authors contributed equally to this work. Departamento de Química Orgânica, Instituto de Química, Universidade Federal Rural do Rio de Janeiro, 23890-000 Seropédica-RJ, Brazil . Otávio A. Chaves. Berghot, New Unexpected Products during Heteroannulation of 1,4-naphthoquinone derivatives, Chem. General procedure for preparing mono- (3a-g) and disubstituted 1,4-naphthoquinones (4a-d, 4f-g) from 2,3-dichloro-1,4-naphthoquinone (1) Synthesis, Biological, and Computational Study of Naphthoquinone Derivatives Containing Heteroatoms. These findings could be useful in the development of MNQand. Four-dimensional quantitative structure-activity relationship (4D-QSAR) models were developed to predict biological activity of 1,4-naphthoquinones derivatives tested against human HL-60 leukemic cells, in order to better investigate the action mode of these compounds. Quinones can generate reactive oxygen species (ROS) through the activation by the cytochrome P450 and P450 reductase enzymes. 1,4-naphthoquinone derivatives have powerful pharmacological effects of antimicrobial and antitumor activities [Chung Y. Shin Y.K. Zhan C.G. Lee S. Cho H. Synthesis and evaluation of antitumor activity of 2- and 6-[(1,3-benzothiazol-2-yl)aminomethyl]-5,8-dimethoxy-1,4-naphthoquinone derivatives. Arch. 1,4-Naphthoquinones are an important class of compounds present in a number of natural products. In this study, a new series of 1,4-naphthoquinone derivatives were synthesized. All the synthesized compounds were tested for in vitro antimicrobial activity. In this present investigation, two Gram-positive and five Gram-negative bacterial strains.

Molecules | Free Full-Text | Synthesis and Biological1,4-Naphthoquinone - Wikipedia

DOI: 10.25135/ACG.OC.26.17.07.040 Corpus ID: 102862265. Synthesis and biological assessment of novel acylhydrazone derivatives of 2-methyl-1,4- naphthoquinone @inproceedings{Bouhadir2017SynthesisAB, title={Synthesis and biological assessment of novel acylhydrazone derivatives of 2-methyl-1,4- naphthoquinone}, author={K. Bouhadir and H. Atallah and Rana Mezher and Maamoun Fatfat and H. Gali. Notes Bull. Korean Chem. Soc. 2007, Vol. 28, No. 4 691 Dependence of Antitumor Activity on the Electrophilicity of 2-Substituted 1,4-Naphthoquinone Derivatives Yongseog Chung: Jikang Yoo, Si-Hyun Park,* Bok Hee Kim,§ Xi Chen,# Chang-Guo Zhan,#,* and Hoon Cho* Department ofPolymer Science & Engineering, Chosun University, Gwangju 501-759, Korea. *E-mail: hcho@chosun.ac.k The production of six naphthoquinone derivatives, erythrostominone, deoxyerythrostominone, 4-O-methyl erythrostominone, epierythrostominol, deoxyerythrostominol, and 3,5,8-trihydroxy-6-methoxy-2-(5-oxohexa-1,3-dienyl)-1,4-naphthoquinone, was examined during the growth of Cordyceps unilateralis Bee 1869 on different carbon and nitrogen sources. Erythrostominone production by the fungus.

The tested hydroxy-naphthoquinone derivatives were setting in the School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil , namely: 2-aniline-3-hydroxy-1,4-naphthoquinone, 2-chloro-aniline-3-hydroxy-1,4-naphthoquinone, 4-methoxy-aniline-3-hydroxy-1,4-naphthoquinone and 2.6-dimethyl-aniline-3-hydroxy-1.4-naphthoquinone, from now on designated as 4a-4d, respectively 1,4-naphthoquinone derivatives and nifurtimox have been studied. Compared to nifurtimox (IC50 = 10.67 µM), all the imido-naphthoquinone analogs (IMDNQ1-IMDNQ11) are more potent on Trypanosoma cruzi with IC50 values ranging from 0.7 µM to 6.1 µM (p < 0.05). Studies of the cytotoxic activities of these compounds on a Balb/C 3T3 mouse fibroblast cell line revealed that four of these compounds. 2,3-Dimethyl-1,4-naphthoquinone Derivatives as Bioreductive Alkylating Agents with Cross-Linking Potential' Tai-Shun Lin,* Ippolito Antonini,2 Lucille A. Cosby, and Alan C. Sartorelli Department of Pharmacology and Developmental Therapeutics Program, Comprehensive Cancer Center, Yale University School of Medicine, N e w Haven, Connecticut 06510. Received November 21, 1983 Bioreducible 2,3. Bioorganic & Medicinal Chemistry Letters 14 (2004) 2901-2904 Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents Vishnu K. Tandon,a,* Ravindra V. Singhb and Dharmendra B. Yadava a Department of Chemistry, Lucknow University, Lucknow 226007, India b GEITC, Corporation, Bangalore 37, India Received 4 February 2004; accepted 12 March. ABSTRACT. A series of S-, S,S-, S,O-, N- and N,S-derivatives from 2,3-dichloro-1,4-naphthoquinone compound 1 were synthesized in different reaction media and evaluated for their antibacterial and antifungal activities. The structures of the novel products were characterized by spectroscopic methods, such as microanalysis, 1 H NMR, 13 C NMR and MS. Among the tested compounds 9, 12 and 18 are.

Naphthoquinone forms the central chemical design of numerous natural compounds, most notably the K vitamins. 2-Methyl-1,4-naphthoquinone, required menadione, is a more effective coagulant than vitamin K.. Other natural naphtoquinones increase juglone, plumbagin, droserone.. Naphthoquinone derivatives micturate significant pharmacological properties. They are cytotoxic, they hit significant. Vitamin K - Menadione - 1,2-Naphthoquinone - Hydroxynaphthoquinone - Quinone - Organic compound - Naphthalene - 1,4-Benzoquinone - Petroleum ether - Alkali - Isomer - Chromium trioxide - Diels-Alder reaction - Butadiene - Cycloaddition - Tin(IV) chloride - Anthraquinone - Juglone - Plumbagin - Droseraceae - Derivative (chemistry) - Cytotoxicity - Antibiotic - Antifungal - Antiviral dru Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives. Alcides J.M. da Silva . Chaquip D. Netto . Wallace Pacienza-Lima . Eduardo Caio Torres-Santos . Bartira Rossi-Bergmann . Severine Maurel . Alexis Valentin . Paulo R.R. Costa . About the authors. Abstracts . Pterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous. Hathaway, Naphthoquinone antimalarials; 2-hydroxy-3-substituted-aminoethyl derivatives by the Mannich reaction, Journal of the American Chemical Society, vol. Synthesis, SAR, and Docking Studies Disclose 2-Arylfuran-1,4-naphthoquinones as In Vitro Antiplasmodial Hit

Define 1,4-naphthoquinone. 1,4-naphthoquinone synonyms, 1,4-naphthoquinone pronunciation, 1,4-naphthoquinone translation, English dictionary definition of 1,4-naphthoquinone. Noun 1. naphthoquinone - a fat-soluble vitamin that helps in the clotting of blood antihemorrhagic factor, vitamin K fat-soluble vitamin - any vitamin that... 1,4-naphthoquinone - definition of 1,4-naphthoquinone by The. Synonyms for 1,4-naphthoquinone in Free Thesaurus. Antonyms for 1,4-naphthoquinone. 2 synonyms for naphthoquinone: antihemorrhagic factor, vitamin K. What are synonyms for 1,4-naphthoquinone

the corresponding 1,4-naphthoquinone 11 d in high yield (96%). Rather than providing the desired product 12, however, the Diels-Alder cycloaddition between 11 d and 1 a afforded a pair of diastereoisomers, 13/14 (64 : 36), in 85% overall yield. They were separated by purification with column chromatog-raphy (Scheme 6). Notably, only the ortho regioisomer (relative to the gem disubstituted. Certain 1,4-naphthoquinone derivatives of the general formula <IMAGE> in particular the compounds plumbagin and lapacholes, have been shown to increase phagocytosis in high dilutions and are used according to the invention in concentrations in the range from 10<-3> to 10<-6> mg/ml for immunostimulation In this manuscript, we designed and synthesized 1,4-naphthoquinone derivatives. These derivatives were characterized using the different analytical techniques such as 1H NMR, 13C NMR, FTIR, Mass spectroscopy, melting point, and elemental analysis. The synthesized compounds (MB (1-10)) further subjected to assess the anticancer activity using different cancer cell lines such as MCF-7, HeLa, and.

Video: Naphthoquinone-derivative as a synthetic compound to

Synthesis, antibacterial and antifungal activities ofArturo ESTOLANO COBIÁN | Master of Science | Autonomous

Synthesis and evaluation of 1,4-naphthoquinone ether

Derivatives of 1,4-naphthoquinone have excellent anti-cancer effects, but their use has been greatly limited due to their serious side effects. To develop compounds with decreased side effects and improved anti-cancer activity, two novel types of 1,4-naphthoquinone derivatives, 2,3-dihydro-2,3-epoxy-2-propylsulfonyl-5,8-dimethoxy-1,4-naphthoquinone (EPDMNQ) and 2,3-dihydro-2,3-epoxy-2. Characterization of the 1,4-naphthoquinone derivatives. Strains and Inoculum. The antimicrobial activity of naphthoquinones was evaluated against three strains of M. tuberculosis: a pan-susceptible, H37Rv (ATCC 27294); a mono-resistant to INH (INH R - ATCC 35822) with mutation in the katG gene (S315T); and a mono-resistant to RIF (RMP R - ATCC 35838) with mutation in rpoB gene (H526Y). All. Amino derivatives of 1,4-naphthoquinone exhibit certain types of biological activity, in particular antibacterial, antifungal, as well as chelating activity for the transport of trace elements due to the presence in the structure of the quinone fragment and the corresponding substituents. The modification of chloro derivatives of 1,4-naphthoquinone by amine-containing compounds uses the.

Molecules | Free Full-Text | Synthesis and AntimicrobialNaphthoquinones; Naphthalenediones; Naphthazarins

1,4-Naphthoquinone - Wikipedi

1,2,3-triazole-1,4-naphthoquinone derivatives towards the human CRC cell line. In addition, we evaluate the involve-ment of voltage-gated calcium channels in the cytotoxic mechanisms. Materials and methods Drugs The 1,4-naphthoquinone derivatives ((N1, N2, N3 or N4), Fig. 1A) were synthesized at the Laboratory for Synthesis of Bioactive Compounds (UFRPE, Brazil) as previously reported. Naphthoquinone colouring matters. Part 1. Synthesis and electronic absorption spectra of 1,4-naphthoquinone derivatives with electron-donating groups in the quinonoid ring K. Chu and J. Griffiths, J. Chem. Soc., Perkin Trans. 1, 1978, 1083 DOI: 10.1039/P1978000108 Yatchang, Marina Fosso, Synthesis and Biological Activity of Aminoglycosides and 1,4-Naphthoquinone Derivatives (2012). All Graduate Theses and Dissertations. 1371. https://digitalcommons.usu.edu/etd/1371 Download DOWNLOADS. Since December 14, 2012. Included in. Chemistry Commons. Share. This is in accordance with a previous study; 1,4-naphthoquinone and its derivatives displayed antibacterial activity against bacteria such as S. aureus and P. aeruginosa. 10,20 Generally, a higher concentration of 1,4-naphthoquinone or plumbagin was required to kill Gram-negative bacteria than Gram-positive bacteria. This is as expected because Gram-negative bacteria possess an outer. naphthalene-1,4-dione derivatives possessing naphthoquinone and resorcinol rings as potential Hsp90 inhibitors. Furthermore, we designed related imines, which are lacking in naphthoquinone moiety, to investigate the role of naphthoquinone ring in biological activity of the designed Figure 1. Synthesis of Novel Naphthoquinones as Anticancer Agents 17. Golmakaniyoon S et al. / IJPR (2019), 18 (1.

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1,4-Naphthoquinone derivatives - Big Chemical Encyclopedi

Halogen derivatives of 1,4-naphthoquinone presented strong activity, e.g., 2-bromo-5-hydroxy-1,4-naphtho-quinone, which exhibited inhibition at an MIC of 16 lg/ mL in S. aureus, and 2-chloro-5,8-dihydroxy-1,4-naph-thoquinone, with an MIC of 2 lg/mL in C. krusei. These compounds showed higher activity against fungi, but the antibacterial activities were very low. The study of structure. New pyrimidinone-fused 1,4-naphthoquinone derivatives inhibit the growth of drug resistant oral bacteria Kyungmin Kim, Daseul Kim, Hyunjin Lee, Tae Hoon Lee, Ki Young Kim , Hakwon Kim College of Life Science Definitions of 1,4-naphthoquinone, synonyms, antonyms, derivatives of 1,4-naphthoquinone, analogical dictionary of 1,4-naphthoquinone (English 1,4-naphthoquinone derivatives and nifurtimox have been studied. Compared to nifurtimox (IC50 = 10.67 µM), all the imido-naphthoquinone analogs (IMDNQ1-IMDNQ11) are more potent on Trypanosoma cruzi with IC50 values ranging from 0.7 µM to 6.1 µM (p < 0.05). Studies of the cytotoxic activities of these compounds on a Balb/C 3T3 mouse fibroblast cell line revealed that four of these compounds.

Synthesis of newly functionalized 1,4-naphthoquinone

The general preparation of 2-hydroxy-1,4-naphthoquinone derivatives was achieved by Mannich reaction according to an adopted procedure that had been previously reported. 32) A mixture of the 2-hydroxy-1,4-naphthoquinone (0.50 mmol) and an amine (0.55 mmol) in absolute ethanol (10 mL) was stirred and heated at 45 °C for 5 min. An aldehyde (0.55 mmol) was then added and the solution was. 1,4-Naphthoquinone or para-naphthoquinone is an organic compound derived from naphthalene. It forms volatile yellow triclinic crystals and has a sharp odor similar to benzoquinone. It is almost insoluble in cold water, slightly soluble in petroleum ether, and more soluble in polar organic solvents. In alkaline solutions it produces a reddish-brown color. Vitamin K is a derivative of 1,4. The aim of this work is to synthesize, characterize and evaluate the biological activity of 1,4-naphthoquinone derivatives ligands and their metal—Co(II), Ni(II) and Cu(II) chelates. Continuing our work with another derivatives of 1,4-naphthoquinone ligands, this work had been constructed for synthesis of new ligands derived from 1,4-naphthoquinone such as 3-thioacetyl-2-amino-1,4. 1,4-Naphthoquinone and its derivatives exhibited several interesting and different biological responses including antibacterial,3 antifungal,4,5 anti-inflammatory, antiplatelet, antiallergic,6 antithrombotic,7 antiviral,8 anticancer,9-11 apoptosis,12 lipoxygenase,13,14 radical scavenging15 and anti-ringworm16 activities. Recently, 1,4-Naphthoquinone derivatives were proved to be human DNA. As the reports related to antiproliferative effects of similar compounds are not common in the literature, we also searched the activity of starting compound 1 on HeLa cells, t

New Pyrimidinone-Fused 1,4-Naphthoquinone Derivatives

Top PDF 4- naphthoquinone were compiled by 1Library. The amino acid derivatives of 1,4-naphthoquinone (1-3), with aliphatic amino acids which do not contain side chains, were chosen for the synthesis of chlorides, thus was reduced the probability of occurrence of side reactions due to the fewer number of reaction centers in the amino acid derivatives of 1,4-naphthoquinone (1-3) molecules The synthesis of 2-hydroxy-1,4-naphthoquinone derivatives compounds was conducted which involves the precursors aromatic aldehyde variations (benzaldehyde, cinnamaldehyde, and 4-hydroxy benzaldehyde), and lawsone using iodine catalyst. The products were confirmed by UV-Vis, FTIR, and GC-MS obtained three 2-hydroxy-1,4- naphthoquinone derivatives, namely 2-(hydrazino-phenyl-methyl)-3-hydroxy-2. These findings demonstrate that glutathionyl conjugates of 1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone and those of their respective 5-hydroxy derivatives are able to act as substrates for DT-diaphorase and that they also autoxidize at rates higher than those for the unsubstituted parent compounds. These results are discussed in terms of the cellular role of DT-diaphorase in the. DOPO derivatives; Water Treatment Chemicals; Biodegradable Chemical; VAT DYES; Electronic/ Pharm chemicals; PRODUCTS . 1,4-Naphthoquinone, CAS 130-15-4; Anthraquinone-2,7-Disulfonic Acid Disodium Salt, CAS 853-67-8; 2-Methyl Anthraquinone, CAS 84-54-8; 2,5-Dihydroxy-1,4-benzoquinone, CAS 615-94-1; 1,4-Dihydroxyanthraquinone; 2-Chloro-1,4-Naphthoquinone, CAS 1010-60-2; 2-Hydroxy-1,4.

In vitro antiplasmodial activity, pharmacokinetic profiles

The 1,4-naphthoquinone derivatives suppressed the growth of lung cancer cells with the lower IC 50 values and lower cytotoxicity in normal cell lines. HHDMNQ had higher efficiency and lower cytotoxicity than HEDMNQ. Furthermore, HHDMNQ induced cell cycle arrest at the G2/M phase by regulating the CDK/cyclin complex in A549 lung cancer cells. Induction of cell apoptosis is a crucial. Naphthalene-1,4-dione derivatives were synthesized and tested against selected bacterial strains. All the tested compounds were prepared by direct introduction of corresponding substituents into the naphthoquinone core in oxidative conditions. In this study, eight strains of bacteria (Proteus, Escherichia, Klebsiella, Staphylococcus, Enterobacter, Pseudomonas, Salmonella, Enterococcus) were. 1,4-naphthoquinone derivatives to the effect on the TBARS content and SOD and CAT activities. results and discussions It was found that the TBARS content in loach embryos at all studied stages of development under the effect of 2-chloro-3-hydroxy-1,4-naphthoqui-none, FO-1, FO-2 decreased in a dose-dependent manner (Table 1). It should be noted that the admini - stration of these compounds at. A series of 2-amino-1,4-naphthoquinone derivatives (NQA-NQF) was synthesized by alternative methods (ultrasonication and microwave irradiation), with yields ranging from 40 to 71%, and without the need of further recrystallization. Each compound was evaluated against four Gram-positive (Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus and Bacillus cereus) and five Gram-negative. The 1,4-naphthoquinone derivative, shikonin, has been shown to increase glucose uptake by adipocytes and myocytes with minor effects on protein tyrosine phosphorylation in the cells ( Biochem Biophys Res Commun 292: 642-651, 2002). The present study was performed to examine the mechanism of this action of shikonin. Shikonin inhibited the phosphatidylinositol 3,4,5-triphosphate (PtdIns-3,4,5-P3. 5,8-Dihydroxy-1,4-naphthoquinone. More... Naphthazarin is a naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 5 and 8 are replaced by hydroxy groups. It has a role as a plant metabolite, an antibacterial agent, an acaricide, an antineoplastic agent and an apoptosis inducer